DSHW-2014-016288 - 0901a068804c7e5a

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Jeff Vandel <[e-mail]>
RE: Memo on Short Term Air Goals - Surrogate Compounds
1 message
Pafmer, Blair <[e-mail]> Mon, Nov 24,2014 at 3:43 PM
To: Jeff Vandel <[e-mail]>, "Hancock, Paul" <[e-mail]>
Cc: Brad Maulding <bmaulding@utah. gov>, Eric Baiden <[e-mail]>
Thanks Jeff. We'll get you an updated Memo.
Blair
From : Jeff Vandel [mailto:[e-mail]]
Sent: Monday, November 24,2014 3:02 PM
To: Palmer, Blair; Hancock, Paul
Cc: Brad Maulding; Eric Baiden
Subject: Memo on Short Term Air Goals - Surrogate Compounds
Blair, Paul -
Mike has finished his review of the list of sunogate compounds in Steve's memo. He is "comfortable" with the
compounds that Steve has compiled in Table 1, so we look good there.
He did recommend reminding you that "the Protocol indicotes thot "surrogate compounds will be used to
represent those compounds based on toxicological properties ond structural similarities." Thus, in
reviewing the HHRA report, we will be looking for a discussion in the uncertointy Section of the tox
properties and structural similarities (compared to the replaced compounds)for eoch identified
surrogote."
lf you would make the changes Mike recommended in his two comments (in previous email) to the
memo and resubmit it to us (by email) we'll approve it as a revision to the approved HHRA Protocol.
We'll then scan these documents to add them to the public record. Please let me know if you have any
questions.
Thanks,
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Jeff
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Jeff Vandel <[e-mail]>
Re: Memo on short term air Goals
1 message
Jeff Vandel <[e-mail]>
To: "Smith, Michael" <[e-mail]>
Mon, Nov 24,2014 at 3:09 PM
Great! l'll pass your recommendations along. I believe we willjust have ATK make the changes you suggested
in your two comments to the memo and resubmit it by email. We'll then approve it as a revision to the approved
HHRA protocol (assuming they make the changes) and then scan the documents to add them to the public
record.
Thanks a lot Mike!
We1l be in touch.
Jeff
On Mon, Nov 24, 2014 at 1:52 PM, Smith, Michael <[e-mail]> wrote:
i Jeff and Eric,
I think l'm comfortable with all the surrogates listed in Table 8-1 of STEVE's memo. I examined 9 of the 17
in some detail the matches with respect to structure, toxicity, and mode of action looked OK.
I would still remind Blair that the Protocol indicates that "surrogate compounds will be used to represent
those compounds based on toxicological properties and structural similarities." Thus, in reviewing the
HHRA report, we will be looking for a discussion in the Uncertainty Section of the tox properties and
structural similarities (compared to the replaced compounds)for each identified surrogate.
Give me a call if you'd like to discuss.
Best,
Mike
678.765.0815
From: Smith, Michael
Sent: Friday, November 2I, 20t4 11:56 AM
To:'JeffVandel'
Subject: RE: Memo on short term air Goals
Jeff,
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l've looked at Steve's memo and tables and have a couple of issues. Also, l've got a question for you. First,
the issues:
1. l'd like any documentation related to the revision of AIEC values to reference the hierarchy in the
"approved" version of the protocol (Section 4.4) and then indicate that values other than the CAL RELs are
taken from Table 2: PAC Rev 27. Steve's memo mentions the CAL RELs as the number 1 source but jumps
right to Table 2: PAC Rev 27 without mentioning the hierarchy. My spot checks indicate this does not
impact any of the numbers listed in Steve's Table 2. AEGL-1's (2nd best source according to the
hierarchylappear to be used where they are available.
2. There is one chemical in Steve's Table 2 for which I found an acute CAL REL (preferred source
according to the hierarchy): methyl bromide @ 3900 ug/m3.
Now my questions for you. I have not checked Steve's Table 1 to see if TechLaw agrees on the surrogates
ATK Promontory has identified. I have checked the tox numbers on the identified in Steve's Table 1 and
none of them are CAL RELs or AEGL-1s so they are from further down the hierarchy. Let me know if you'd
like me to check the identifies. I think it would be better to do it now rather than.wait for the report to be
submitted. However, Eric may prefer to do it rather than Techlaw. Let me know what you'd like to do. lt
will take me a few hours to check them all.
l'll be in after 1 PM EST if you'd like to discuss.
Best,
Mike
678.76s.0815
From r Jeff Vandel [mailto:[e-mail]]
Sent: Tuesday, November L8,20L41:12 PM
To: Smith, Michael
Cc: Eric Baiden; Brad Maulding
Subject: Fwd: Memo on short term air Goals
Hi Mike
Stephen Foster and ATK have updated the memo and tables regarding short-term exposure factors for
inhalation (attached). Could you please take a look at these and see what you think?
Also, Brad was asking about who at Techlaw would be involved in the review of the OB/OD HHRA that is due
December 15th. I told him I want sure. Do you know?
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Thanks for your help,
Jeff
Forwarded message
From: Palmer, Blair <[e-mail]>
Date: Mon, Nov 17, 2014 at 9:48 AM
Subject: Memo on short term air Goals
To: Jeff Vandel <[e-mail]>
Cc: "Hancock, Paul" <[e-mail]>
Hi Jeff, attached is the updated memo on the Short-term Exposure Dose-Response Factors. Please review
these and let us know if you concur with the values we have proposed.
Thanks,
Blair
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